a pilot study of polymorphism of adrenergic beta-2 receptor and mild asthma: a clinical and pharmacogenetic study

نویسندگان

parisa adimi naghan chronic respiratory disease research center, nritld, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran.

fanak fahimi 1- clinical pharmacy department, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. 2- pharmaceutical care department, chronic respiratory disease research center, nriltd, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran.

seyed alireza nadji virology research center, nritld, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran.

nima naderi 1-neuroscience research center, shahid beheshti university of medical sciences, tehran, iran. 2-toxicology department, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

چکیده

glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. this study was designed to evaluate the genetic alleles in mild asthma.thirty-four patients with diagnosis of mild asthma (fev1 ≥ 80%, positive methacholine test) and body mass index (bmi ≤ 30 kg/m2) were included in the study. they could only use short acting beta-2 agonists for asthma control. smoking, infection, occupational sensitizers’ exposure, gastroesophageal reflux, diabetes mellitus and heart failure were also considered as exclusion criteria. all patients were genotyped at 16th and 27th codons.among all, 20 (58.8%) arg/gly, 14 (41.2%) arg/arg and no gly/gly genotype were detected at codon 16. genotyping at codon 27 revealed 2 (5.9%) glu/glu, 13 (38.2%) glu/gln and 18 gln/gln (52.9%).based on the obtained results, arg/gly mutation had a higher rate among the studied subjects compared to arg/arg polymorphism. this is a pilot study which shows a probable usefulness of genotyping for predicting of asthma severity.

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منابع مشابه

A Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study

Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...

متن کامل

A Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study

Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...

متن کامل

A Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study

Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma. Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m(2)) were inc...

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عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۲، شماره ۱، صفحات ۱۹۹-۲۰۴

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